Aminophylline was used to treat the reactions in 3% of patients in the lexiscan group and 2% of patients in the adenoscan group. The name of your medicine is aminophylline hydrate 25mgml solution for injection. Pfizer rxpathways connects eligible patients to a range of assistance programs to help them access their pfizer prescriptions. It will be referred to as aminophylline injection for ease of use hereafter. Aminophylline may be administered in doses ranging from 50 mg to 250 mg by slow intravenous injection 50 mg to 100 mg over 3060 seconds to attenuate severe andor persistent adverse reactions to lexiscan. Pharmaceuticals and medical devices safety information pmda. In a study conducted in healthy adults, coadministration of febuxostat 80 mg po daily resulted in increased theophylline cmax 6% and auc 6. Aminophylline hydrate 25mgml solution for injection. What you need to know before you use aminophylline injection 250 mg in 10 ml 3.
Precautions section of the package insert regarding the. Product monograph midazolam injection usp preservativefree page 30 of 39. Evidence recommendation based on information obtained from initial clinical trials of the medications, product package inserts, and drug databases. Necrosis was slight in the midazolamtreated rabbits and severe in the diazepamtreated animals. Intravenous administration of formulary medications uw health. Aminophylline drug monograph pediatric care online aap point. How to store aminophylline injection 250 mg in 10 ml 6. Aminophylline is converted to the active form, theophylline, in the body. Aminophylline 100 mg, administered by slow iv injection over 60 seconds injected 1 minute after 0. What aminophylline injection 250 mg in 10 ml is and what it is used for 2.
Physician prescribing information aminophylline, vial u. Aminophylline injection, usp contains aminophylline calculated as the dihydrate 25 mgml equivalent to 19. Highlights of prescribing information hypotension, throat. Such prophylactic use is not included in the package inserts of regadenoson, adenosine, or dipyridamole. Before addition of a newly available drug in a patient receiving theophylline, the package insert of the new drug andor the medical literature should be. Aminophylline may be confused with amitriptyline, ampicillin. Aminophylline shortage and current recommendations for reversal. Aminophylline injection aminophylline dihydrate dose. Webmd provides common contraindications for aminophylline intravenous. If symptoms are not controlled and dosage is tolerated, consider adding additional.
What you need to know before you are given aminophylline injection 3. The solution may contain an excess of ethylenediamine for ph adjustment. Most adverse reactions began soon after dosing, and generally resolved within approximately 15 minutes, except for headache which resolved in most patients within 30 minutes. Highlights of prescribing information these highlights do. By inhibiting xanthine oxidase, febuxostat alters theophylline metabolism. Eligible patients can register for valuable savings offers for nearly 40 brand name medications.